O9 - It’s worth a shot: the Science of stopping a global syphilis epidemic, one genome at a time

Moderator(s)

• KG

  Khalil Ghanem, MD, PhD

  Johns Hopkins University School of Medicine, United States
• MC

  Marco Cusini

Presentations:

• 10:00 – 10:15 CST

  The clinical and genomic diversity of Treponema pallidum among early syphilis patients enrolled in a global consortium for syphilis vaccine development
  

  Primary Presenter: Arlene C. Seña, MD, MPH – Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
• 10:15 – 10:30 CST

  Treponema pallidum Proteomic Analysis to Inform Syphilis Vaccine Development
  

  Primary Presenter: Simon Houston, PhD – University of Victoria, Canada
• 10:30 – 10:45 CST

  Syphilis and the Host; multi-omic analysis of host cellular responses to Treponema pallidum provides novel insight into syphilis pathogenesis
  

  Primary Presenter: Sean Waugh, BSc (Hons) – University of Victoria, Canada
• 10:45 – 11:00 CST

  Syphilis vaccine development: Generating a stable and efficacious multi-epitope vaccine chimera through protein engineering
  

  Primary Presenter: Alloysius Gomez, BSc – University of Victoria, Canada
• 11:00 – 11:15 CST

  Persons with Early Syphilis Make Antibodies that Differentially Recognize Extracellular Loops of Treponema pallidum Outer Membrane Proteins
  

  Primary Presenter: M. Anthony Moody, MD – Duke Human Vaccine Institute, Duke Univerity, Durham, North Carolina, USA
• 11:15 – 11:30 CST

  Comparison of Treponema pallidum genomic sequences in clinical samples and rabbit passaged isolates from early syphilis patients in Guangzhou, China
  

  Primary Presenter: Arlene C. Seña, MD, MPH – Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA